Key result
High voltage shocks induce bimodal action potential changes and transient refractoriness in isolated papillary muscles.
Population
Isolated guinea pig and pig papillary muscles during rapid activations simulating ventricular fibrillation
Design
Preclinical
Authors
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High-voltage shock effects on membrane potentials in isolated tissue warrant clinical caution; leaves open their role in defibrillation mechanisms pending intact-heart validation.
High voltage shocks induce bimodal changes in action potential duration and a rate-dependent transient refractory state, which may contribute to the mechanism of successful defibrillation.
LI et al. (1995) studied ventricular fibrillation (simulated). High voltage shocks was evaluated on cellular electrophysiological effects (action potential duration and transient refractoriness). High voltage shocks induced bimodal changes in action potential duration and a transient refractory state during rapid activation in isolated papillary muscles.
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