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July 1, 1989Pain

Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin

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Why the study?

Does intradermal capsaicin injection cause dose-dependent pain and mechanical hyperalgesia in humans?

Population

Human subjects

Comparison

Intradermal injection of capsaicin vs 10 microliter injection of the vehicle

Design

Other

Follow-up

up to 137 minutes

Authors

DSDonald A. SimoneUniversity of MinnesotaTBThomas BaumannChemnitz University of TechnologyRLRobert H. LaMotteYale University

Discussion

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Overview

Establishes titratable capsaicin model for experimental pain research; leaves open clinical translation.

Structured PICO

Does intradermal capsaicin injection cause dose-dependent pain and mechanical hyperalgesia in humans?

P
Population
Human subjects
I
Intervention
Intradermal injection of capsaicin (0.01, 0.1, 1, 10, and 100 micrograms in 10 microliters)
C
Comparator
10 microliter injection of the vehicle
O
Outcome
Magnitude and duration of pain, area of flare, and area and time course of mechanical hyperalgesiapatient reported

Intradermal capsaicin produces dose-dependent pain, flare, and mechanical hyperalgesia in humans, providing a scalable model for pain research.

Cite This Study

Simone et al. (1989) studied this question.

synapsesocial.com/papers/6a7e54cabec2d97a1332f10ahttps://doi.org/10.1016/0304-3959(89)90079-1
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