Why the study?
Does repeated dermal application of capsaicin reduce pain and vasodilatation induced by intradermal injection of acid and hypertonic solutions in healthy volunteers?
Population
13 healthy volunteers
Comparison
Capsaicin painted on the volar skin of one… vs Contralateral forearm treated with capsaicin…
Design
RCT, chosen at random
Follow-up
7 days
Authors
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May guide mechanism-based topical analgesics for acid-mediated pain; extends animal data on distinct nociceptive pathways to human skin via RCT.
Does repeated dermal application of capsaicin reduce pain and vasodilatation induced by intradermal injection of acid and hypertonic solutions in healthy volunteers?
Repeated application of capsaicin to human skin inhibits both sensory and efferent responses to low pH media, but only efferent responses to hypertonic media.
Bianco et al. (1996) studied this question.
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