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April 1, 1999Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

AJvW-2, an Anti-vWF Monoclonal Antibody, Inhibits Enhanced Platelet Aggregation Induced by High Shear Stress in Platelet-Rich Plasma From Patients With Acute Coronary Syndromes

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Why the study?

Does AJvW-2 inhibit enhanced shear-induced platelet aggregation in platelet-rich plasma from patients with acute coronary syndromes?

Population

Platelet-rich plasma from 12 patients with unstable angina, 20 patients with acute myocardial infarction…

Comparison

AJvW-2 10 microgram/mL vs Uninhibited state

Design

Preclinical

Authors

KEKoji EtoChiba UniversityTITakaaki IsshikiInterventional CardiologyHYHiroshi YamamotoShinshu University

Discussion

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Implication

Ex vivo AJvW-2 inhibition of SIPA is hypothesis-generating; prospective trials needed before any clinical consideration in ACS.

Structured PICO

Does AJvW-2 inhibit enhanced shear-induced platelet aggregation in platelet-rich plasma from patients with acute coronary syndromes?

P
Population
Platelet-rich plasma from 12 patients with unstable angina (UAP), 20 patients with acute myocardial infarction (AMI) admitted within 3 hours of symptom onset, and 18 controls (total n=50).
I
Intervention
AJvW-2 (anti-vWF monoclonal antibody) 10 microgram/mL
C
Comparator
Uninhibited state (baseline aggregation without AJvW-2)
O
Outcome
Shear-induced platelet aggregation (SIPA) under high-shear (108 dyne/cm2) and low-shear (12 dyne/cm2) conditionssurrogate

AJvW-2 completely inhibits enhanced high shear-induced platelet aggregation in patients with acute coronary syndromes, suggesting a potential therapeutic role in preventing coronary occlusion.

Cite This Study

Eto et al. (1999) studied this question.

synapsesocial.com/papers/6a7e5e10ef8e9536aa85658fhttps://doi.org/10.1161/01.atv.19.4.877
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abolition of cyclic flow variations in stenosed, endothelium-injured coronary arteries in nonhuman primates with a peptide fragment (VCL) derived from human plasma von Willebrand factor-glycoprotein Ib binding domain.1994 · 64 citations
  2. 2Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets1993 · 273 citations
  3. 3ADP-dependent common receptor mechanism for binding of von Willebrand factor and fibrinogen to human platelets.1984 · 77 citations
  4. 4Epinephrine augments von Willebrand factor-dependent shear-induced platelet aggregation.1992 · 85 citations