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January 1, 1998Thrombosis and Haemostasis

Antagonism of vWF Inhibits both Injury Induced Arterial and Venous Thrombosis in the Hamster

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Why the study?

Does antagonism of vWF inhibit injury-induced arterial and venous thrombosis in a hamster model?

Population

Hamsters with experimental thrombosis induced in the carotid artery and femoral vein, and in vitro human…

Design

Preclinical

Authors

HYHiroshi YamamotoNihon UniversityIVIngrid VreysMaastricht UniversityJSJean Marie StassenMineral Products Association

Discussion

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Implication

vWF A1 antagonism inhibits arterial and venous thrombosis in hamsters; leaves open translation to human antithrombotic strategies.

Structured PICO

Does antagonism of vWF inhibit injury-induced arterial and venous thrombosis in a hamster model?

P
Population
Hamsters with experimental thrombosis induced in the carotid artery and femoral vein, and in vitro human blood perfusion models
I
Intervention
vWF antagonists (anti-human vWF monoclonal antibody AJvW-2 or fractionated aurin tricarboxylic acid [ATA])
O
Outcome
Inhibition of thrombosis in the injured carotid artery and femoral veinsurrogate

Antagonizing the vWF A1 domain inhibits both arterial and venous thrombosis in a hamster model, indicating that vWF participates in injury-induced venous thrombosis.

Cite This Study

Yamamoto et al. (1998) studied this question.

synapsesocial.com/papers/6a7118fea2d7cf2e39c2c09ahttps://doi.org/10.1055/s-0037-1614240
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiple Inhibition of Platelet Activation by Aurintricarboxylic Acid Prevents Vascular Stenosis after Endothelial Injury in Hamster Carotid Artery1998 · 25 citations
  2. 2The Antithrombotic Effect of Aurin Tricarboxylic Acid in the Guinea Pig Is not Solely due to Its Interaction with the von Willebrand Factor-GPIb Axis1996 · 14 citations
  3. 3Aurin Tricarboxylic Acid Inhibits Platelet Adhesion to Collagen by Binding to the 509-695 Disulphide Loop of von Willebrand Factor and Competing with Glycoprotein Ib1992 · 33 citations
  4. 4Contribution of von Willebrand Factor to Thrombus Formation on Neointima of Rabbit Stenotic Iliac Artery Under High Blood-Flow Velocity2003 · 48 citations
  5. 5AJvW-2, an Anti-vWF Monoclonal Antibody, Inhibits Enhanced Platelet Aggregation Induced by High Shear Stress in Platelet-Rich Plasma From Patients With Acute Coronary Syndromes1999 · 37 citations