Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1998Thrombosis and Haemostasis

Multiple Inhibition of Platelet Activation by Aurintricarboxylic Acid Prevents Vascular Stenosis after Endothelial Injury in Hamster Carotid Artery

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does aurintricarboxylic acid prevent vascular stenosis and thrombus formation in a hamster model of endothelial injury?

Population

Hamster model of carotid artery endothelial injury, and in vitro hamster blood and smooth muscle cells (SMCs)

Comparison

Aurintricarboxylic acid administered… vs Control (0 mg/kg per hour)

Design

Preclinical

Follow-up

2 weeks

Discussion

Loading...

Member takes

Implication

ATA attenuates neointimal formation after hamster vascular injury; leaves open translation to human stenosis or thrombosis prevention.

Structured PICO

Does aurintricarboxylic acid prevent vascular stenosis and thrombus formation in a hamster model of endothelial injury?

P
Population
Hamster model of carotid artery endothelial injury, and in vitro hamster blood and smooth muscle cells (SMCs)
I
Intervention
Aurintricarboxylic acid (ATA) administered continuously via infusion pump (doses ranging from 0.1 to 10.0 mg/kg per hour) for up to 2 weeks
C
Comparator
Control (0 mg/kg per hour)
O
Outcome
Time to occlude carotid artery after vascular injury and neointimal areasurrogate

Aurintricarboxylic acid inhibits both platelet adhesion and smooth muscle cell proliferation, effectively reducing neointima formation and thrombosis after vascular injury in a preclinical model.

Cite This Study

A 1998 study studied this question.

synapsesocial.com/papers/6a853e73b890443775b2f032https://doi.org/10.1055/s-0037-1615079

Topics

Dual antiplatelet therapy
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aurintricarboxylic Acid Reduces Platelet Deposition in Stenosed and Endothelially Injured Rabbit Carotid Arteries more Effectively than other Antiplatelet Interventions1995 · 22 citations
  2. 2Aurintricarboxylic Acid Attenuates Intimal Thickening after Balloon Injury of the Rabbit Aorta2002 · 6 citations
  3. 3The Antithrombotic Effect of Aurin Tricarboxylic Acid in the Guinea Pig Is not Solely due to Its Interaction with the von Willebrand Factor-GPIb Axis1996 · 14 citations
  4. 4Aurin Tricarboxylic Acid Inhibits Platelet Adhesion to Collagen by Binding to the 509-695 Disulphide Loop of von Willebrand Factor and Competing with Glycoprotein Ib1992 · 33 citations
  5. 5Antagonism of vWF Inhibits both Injury Induced Arterial and Venous Thrombosis in the Hamster1998 · 63 citations