Key result
Aurintricarboxylic acid reduced intimal thickening 2 weeks after balloon-induced injury to the rabbit aorta, whereas aspirin had no effect.
Why the study?
Does aurintricarboxylic acid attenuate intimal thickening after balloon injury in a rabbit aorta model?
Population
Rabbit aorta model with balloon-induced injury
Design
Preclinical
Follow-up
2 weeks
Authors
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ATA shows promise vs aspirin in rabbit restenosis model; leaves open human translation pending further study.
Does aurintricarboxylic acid attenuate intimal thickening after balloon injury in a rabbit aorta model?
Inhibition of von Willebrand factor function with ATA, but not aspirin, attenuates intimal thickening after arterial injury in a rabbit model.
Waissbluth et al. (2002) studied Balloon-induced arterial injury. Aurintricarboxylic acid (ATA) vs. Aspirin was evaluated on Intimal thickening and vascular procoagulant activity. Aurintricarboxylic acid reduced intimal thickening 2 weeks after balloon-induced injury to the rabbit aorta, whereas aspirin had no effect.
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