Why the study?
Does locally delivered argatroban using a hydrogel-coated balloon catheter reduce intimal thickening in a rabbit model of carotid artery injury?
Population
Rabbit model of carotid artery injury (rabbit common carotid artery), n=29
Comparison
Locally delivered argatroban via hydrogel-coated… vs Hydrogel-coated balloon catheter immersed in…
Design
Preclinical
Follow-up
20 days
Authors
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Local argatroban delivery attenuates neointimal formation in rabbits; leaves open translation to clinical restenosis prevention.
Does locally delivered argatroban using a hydrogel-coated balloon catheter reduce intimal thickening in a rabbit model of carotid artery injury?
Locally administered argatroban via a hydrogel-coated balloon catheter dose-dependently inhibits intimal thickening following balloon injury in a rabbit model.
Imanishi et al. (1997) studied this question.
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