STAT 5a, STAT 5b, and NF-Y are key transcription factors mediating the sexually dimorphic, growth hormone-dependent regulation of CYP3A10/6beta-hydroxylase.
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Preclinical data warrant no clinical change; extends mechanistic understanding of GH-regulated, sexually dimorphic CYP3A expression in models.
Aravind Subramanian (1998) studied this question.
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