Why the study?
Does endogenous atrial natriuretic factor modulate pulmonary vascular tone in rats with hypoxic pulmonary hypertension?
Population
Rats with hypoxic pulmonary hypertension (exposed to hypoxia for 3 weeks) and normoxic rats
Comparison
Atrial natriuretic factor monoclonal antibody or… vs Control ascitic fluid containing monoclonal…
Design
Preclinical
Follow-up
3 weeks
Authors
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Supports protective role of endogenous ANF in hypoxic PH; leaves open whether ANF modulation merits human trials.
Does endogenous atrial natriuretic factor modulate pulmonary vascular tone in rats with hypoxic pulmonary hypertension?
Endogenous atrial natriuretic factor attenuates hypoxic pulmonary hypertension by decreasing pulmonary vascular tone in a rat model.
Raffestin et al. (1992) studied this question.
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