Why the study?
Do preoperative PET perfusion and metabolic findings correlate with ultrastructural patterns and postoperative functional improvement in patients with CAD and ischemic dysfunction?
Population
24 patients with coronary artery disease and anterior wall dysfunction undergoing bypass surgery
Comparison
Preoperative dynamic PET with [13N]ammonia and… vs Myocardium with postoperative functional…
Design
Cohort
Authors
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PET metrics may aid viability assessment in CAD; hypothesis-generating for glycogen/fibrosis links, needing prospective validation before practice change.
Do preoperative PET perfusion and metabolic findings correlate with ultrastructural patterns and postoperative functional improvement in patients with CAD and ischemic dysfunction?
Preoperative PET perfusion and glucose uptake correlate with myocardial viability, characterized by less fibrosis and more cardiomyocytes with excess glycogen, predicting functional recovery after revascularization.
Depre et al. (1995) studied this question.
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