Why the study?
Does chronic anthracycline administration alter systolic time intervals in a rabbit model of congestive heart failure?
Does chronic anthracycline administration alter systolic time intervals in a rabbit model of congestive heart failure?
In a rabbit model, anthracycline-induced congestive heart failure is characterized by prolonged preejection period and shortened left ventricular ejection time, similar to human heart failure.
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May indicate LV failure in anthracycline rabbit models; human translation unproven and should not change practice.
Long et al. (1983) studied this question.
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