Population
21 rabbits (5 for autonomic blockade validation, 16 for doxorubicin-induced congestive heart failure model)
Comparison
Doxorubicin 1 mg/kg twice weekly for 4 and 6… vs Baseline and normal rabbits
Design
Preclinical
Follow-up
6 weeks
Authors
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Suggests sympathetic activation via LF power in doxorubicin CHF models; leaves open translation to human exercise responses.
Power spectral analysis of heart rate variability reflects sympathetic activation in a rabbit model of doxorubicin-induced heart failure, though exercise responses are paradoxical.
Moguilevski et al. (1995) studied this question.
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