Why the study?
Does atenolol compared to oxprenolol preserve respiratory function in patients with angina or hypertension and co-existent chronic airways obstruction?
Does atenolol compared to oxprenolol preserve respiratory function in patients with angina or hypertension and co-existent chronic airways obstruction?
Cardioselective beta-blockers like atenolol are safer for respiratory function than non-selective beta-blockers with partial agonist activity like oxprenolol in patients with co-existent chronic airways obstruction.
Supports atenolol over oxprenolol in patients with coexistent airways obstruction; confirms cardioselectivity advantages for respiratory safety.
1 The effects of atenolol (50 mg and 100 mg) and oxprenolol (80 mg) on respiratory function were studied in ten patients with angina pectoris or hypertension complicated by chronic airways obstruction. 2 In patients with "fixed" airways obstruction, neither atenolol nor exprenolol significantly affected airways resistance. 3 In patients with "labile" airways obstruction, atenolol did not produce a significant increase in airways obstruction, whereas oxprenolol did. 4 Following isoprenaline challenge (1500 microgram by inhalation), atenolol permitted full bronchodilatation, whereas oxprenolol almost completely blocked the action of isoprenaline. 5 Partial agonist activity appears to be of less clinical importance than cardioselectivity.
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Perks et al. (1978) studied this question.
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