Key result
Beta-blockers with intrinsic sympathomimetic activity (oxprenolol and practolol) demonstrated a flattening of the dose-response curve for exercise heart rate reduction compared to those without ISA.
Why the study?
Does intrinsic sympathomimetic activity (ISA) or cardioselectivity influence the dose-response effect of beta-blockers on exercise heart rate in healthy volunteers?
Population
Healthy volunteers
Comparison
Beta-blockers with and without intrinsic… vs Historical dose-response curves for sotalol…
Design
Other
Authors
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ISA may alter beta-blocker dosing for HR control; hypothesis-generating and requires validation in patients.
Does intrinsic sympathomimetic activity (ISA) or cardioselectivity influence the dose-response effect of beta-blockers on exercise heart rate in healthy volunteers?
The presence of intrinsic sympathomimetic activity in beta-blockers can be demonstrated in humans by a flattening of the dose-response curve for exercise heart rate reduction.
McDevitt et al. (1977) studied Healthy volunteers. Beta adrenoceptor-blocking drugs (propranolol, oxprenolol, sotalol, practolol, atenolol) vs. Comparisons among different beta-blockers was evaluated on Percentage reduction in exercise heart rate (EHR). Beta-blockers with intrinsic sympathomimetic activity (oxprenolol and practolol) demonstrated a flattening of the dose-response curve for exercise heart rate reduction compared to those without ISA.
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