March 1, 1973Cardiovascular Research

Cardiospecificity of ( -receptor blockade: A comparison of the relative potencies on cardiac and peripheral vascular ( -adrenoceptors of propranolol, of practolol and its ortho-substituted isomer, and of oxprenolol and its para-substituted isomer

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Population

Anaesthetized dogs

Comparison

Propranolol, practolol, ortho-substituted isomer… vs Comparison among the different beta-blocker…

Design

Preclinical

Authors

EWE. M. Vaughan WilliamsHaffkine Institute EBE. E. BagwellClemson University BSBramah N. SinghElectrophysiology

Discussion

Member takes

Implication

Supports cardiospecific beta-blocker design in animals; leaves open human translation and clinical utility.

Structured PICO

Population

Anaesthetized dogs

Intervention

Propranolol, practolol, ortho-substituted isomer of practolol, oxprenolol, and para-substituted isomer of oxprenolol

Comparator

Comparison among the different beta-blocker compounds

Outcome

Relative potencies in blocking the effects of isoprenaline on peripheral blood flow and heart ratesurrogate

Specific structural modifications of beta-blockers, such as para-substitution in oxprenolol, can confer total cardiospecificity in blocking beta-adrenoceptors.

Cite This Study

Williams et al. (1973) studied this question.

synapsesocial.com/papers/6a7055c4febe604dd7092056 https://doi.org/10.1093/cvr/7.2.226

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Cardiospecificity of ( -receptor blockade: A comparison of the relative potencies on cardiac and peripheral vascular ( -adrenoceptors of propranolol, of practolol and its ortho-substituted isomer, and of oxprenolol and its para-substituted isomer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiospecificity of ( -receptor blockade: A comparison of the relative potencies on cardiac and peripheral vascular ( -adrenoceptors of propranolol, of practolol and its ortho-substituted isomer, and of oxprenolol and its para-substituted isomer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider