Why the study?
Do different beta-blockers exhibit class III antiarrhythmic effects in rabbit ventricular muscle?
Population
Rabbit right ventricular papillary muscle studied in vitro
Comparison
Various concentrations of atenolol, metoprolol… vs Comparison among the different beta-blockers and…
Design
Preclinical
Authors
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Sotalol's class III selectivity in rabbit tissue supports targeted antiarrhythmic development; leaves open translation to human arrhythmia therapy.
Do different beta-blockers exhibit class III antiarrhythmic effects in rabbit ventricular muscle?
Sotalol, particularly D-sotalol, exhibits class III antiarrhythmic properties at clinically relevant concentrations, suggesting potential utility as an antiarrhythmic agent with reduced beta-blocking side effects.
MANLEY et al. (1986) studied this question.
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