June 26, 2009Obesity Reviews
Natriuretic peptides: linking heart and adipose tissue in obesity and related conditions – a systematic review
Population
75 studies investigating obese patients, especially those with hypertension and metabolic risk factors.
Design
Systematic_review
Authors
Discussion
Loading...
Member takes
Implication
Obese patients may require adjusted natriuretic peptide thresholds; confirms the paradox and extends investigation of its metabolic consequences.
Structured PICO
P
Population
75 studies investigating obese patients, especially those with hypertension and metabolic risk factors.
O
Outcome
Association between natriuretic peptides, obesity, and related comorbiditiessurrogate
Obese patients exhibit paradoxically reduced levels of natriuretic peptides, which may be involved in the pathophysiology of obesity due to their lipolytic effects.
Limitations
- Selection of subjects and classification of obesity and heart failure varied among the reviewed studies, rendering comparison unreliable.
Cite This Study
Beleigoli et al. (2009) studied this question.