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April 1, 1996Arteriosclerosis Thrombosis and Vascular Biology

Triple Drug Immunosuppression Significantly Reduces Aortic Allograft Arteriosclerosis in the Rat

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Why the study?

Does triple drug immunosuppression reduce allograft arteriosclerosis in rat aortic allografts?

Population

Rat aortic allografts from the DA (AG-B4,RT1a) to the WF (AG-B2,RT1u) strain, n=46

Comparison

Triple drug immunosuppression vs Untreated controls

Design

Preclinical

Follow-up

up to 180 days

Authors

KLKarl LemströmUniversity of HelsinkiARAnne Räisänen‐SokolowskiUniversity of HelsinkiPHP HäyryThe Wistar Institute

Discussion

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Implication

Hypothesis-generating in rat allografts; leaves open translation to human transplant arteriosclerosis prevention.

Structured PICO

Does triple drug immunosuppression reduce allograft arteriosclerosis in rat aortic allografts?

P
Population
Rat aortic allografts from the DA (AG-B4,RT1a) to the WF (AG-B2,RT1u) strain, n=46
I
Intervention
Triple drug immunosuppression (cyclosporine A 10 mg/kg/d, methylprednisolone 0.5 mg/kg/d)
C
Comparator
Untreated controls
O
Outcome
Development of allograft arteriosclerosis (intimal thickening) evaluated by quantitative histologysurrogate

Triple drug immunosuppression effectively reduces the development of allograft arteriosclerosis by down-regulating the inflammatory response and immune activation in a rat model.

Cite This Study

Lemström et al. (1996) studied this question.

synapsesocial.com/papers/6a7e6ee29408b4785c8f499bhttps://doi.org/10.1161/01.atv.16.4.553
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.1984 · 612 citations
  2. 2Cyclosporin a modulation of tumor necrosis factor gene expression and effects in vitro and in vivo.1990 · 75 citations
  3. 3Introduction to Linear Regression Analysis.1993 · 5,429 citations
  4. 4Additive and synergistic effects of a low-molecular-weight, heparin-like molecule and low doses of cyclosporin in preventing arterial graft rejection in rats.1993 · 24 citations