Why the study?
Does high anticholinergic cognitive burden increase the risk of dementia in older adults with subjective cognitive decline?
Population
109 older adults with subjective cognitive decline (SCD), mean age 72.5, 66.1% female
Comparison
High anticholinergic cognitive burden (ACB ≥ 3) vs No or low anticholinergic cognitive burden
Design
Cohort
Follow-up
median 75 months (range, 36–185)
Authors
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Supports minimizing anticholinergic burden in older adults with subjective cognitive decline; leaves open whether depres.
Does high anticholinergic cognitive burden increase the risk of dementia in older adults with subjective cognitive decline?
High anticholinergic cognitive burden is associated with a significantly increased risk of progression to dementia in older adults with subjective cognitive decline.
Naharcı et al. (2017) studied this question.
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