Why the study?
Do anesthetics attenuate the renal sympathetic response to anaphylactic hypotension in sensitized rats compared to the conscious state?
Population
Sprague-Dawley rats sensitized with subcutaneously injected ovalbumin
Comparison
Anesthesia with pentobarbital, urethane, or… vs Conscious state (no anesthesia)
Design
Preclinical, randomly allocated
Follow-up
40 minutes post-antigen injection
Authors
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Anesthetics may blunt sympathoexcitation in rat anaphylaxis models; leaves open translation to human perioperative responses.
Do anesthetics attenuate the renal sympathetic response to anaphylactic hypotension in sensitized rats compared to the conscious state?
Anesthetics attenuate antigen-induced renal sympathoexcitation during anaphylactic hypotension in rats through the suppression of baroreceptor function.
Sun et al. (2014) studied this question.
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