Why the study?
Does mRNA in situ hybridization of steroidogenic enzyme genes improve postoperative subclassification and predict cure in patients with primary aldosteronism undergoing adrenalectomy?
Population
27 patients subjected to adrenalectomy for primary aldosteronism
Design
Cohort
Authors
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CYP11B2 expression was associated with cure after adrenalectomy; supports postoperative PA subclassification but leaves open need for prospective validation.
Does mRNA in situ hybridization of steroidogenic enzyme genes improve postoperative subclassification and predict cure in patients with primary aldosteronism undergoing adrenalectomy?
mRNA in situ hybridization of CYP11B2 in resected adrenals helps correctly subclassify primary aldosteronism postoperatively and explains cases not cured by adrenalectomy.
Enberg et al. (2004) studied this question.
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