Why the study?
It was hypothesized that the LEGEND rule-out strategy would reduce length of stay, increase safe discharges within 4 hours, reduce cardiac testing, and decrease representations while maintaining safety.
Does the LEGEND rule-out strategy reduce hospital length of stay in adult patients presenting to the emergency department with suspected acute coronary syndrome?
Population
9,944 adult patients presenting with suspected ACS
Comparison
LEGEND rule-out strategy vs standard care
Design
Stepped-wedge cluster randomized controlled trial in 4 emergency departments
Follow-up
30 days
Authors
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May enable faster safe ED discharge in suspected ACS; extends single hs-cTn rule-out evidence to stepped-wedge RCT.
Does the LEGEND rule-out strategy reduce hospital length of stay in adult patients presenting to the emergency department with suspected acute coronary syndrome?
The LEGEND rule-out strategy safely reduces hospital length of stay and cardiac testing while increasing 4-hour discharges for emergency department patients with suspected ACS.
Greenslade et al. (2025) studied this question.
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