Why the study?
Does combined administration of progressively increasing doses of a long-acting oral anticoagulant and heparin prevent skin necrosis in patients with severe congenital protein C deficiency?
Population
Patient with severe congenital protein C deficiency and previous skin necrosis at the initiation of oral…
Design
Case_report
Authors
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Supports heparin overlap during gradual oral anticoagulation in protein C deficiency; leaves open prospective validation for skin necrosis prevention.
Does combined administration of progressively increasing doses of a long-acting oral anticoagulant and heparin prevent skin necrosis in patients with severe congenital protein C deficiency?
Progressive initiation of oral anticoagulants with therapeutic heparin overlap can prevent skin necrosis in patients with severe protein C deficiency.
Samama et al. (1984) studied this question.
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