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November 15, 2019NutrientsOpen Access

PPB and ECE attenuated HFD-induced PVAT dysfunction and endothelial dysfunction by decreasing inflammation (M1 macrophages, MCP-1, TNF-α, IL-6), reducing ER stress, and enhancing the pAMPK-PI3K-peNOS pathway.

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Why the study?

Does Ecklonia Cava Extract (ECE) or PPB attenuate endothelial cell dysfunction in a high-fat diet-induced model of PVAT dysfunction?

Comparison

ECE and PPB vs high fat diet

Authors

MSMyeongjoo SonSOSeyeon OhHLHye Sun Lee

Discussion

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Overview

Hypothesis-generating for ECE/PPB in diet-induced vascular protection; leaves open clinical translation pending human trials.

Structured PICO

Does Ecklonia Cava Extract (ECE) or PPB attenuate endothelial cell dysfunction in a high-fat diet-induced model of PVAT dysfunction?

P
Population
High-fat diet (HFD)-induced model of perivascular fat tissue (PVAT) dysfunction
I
Intervention
Ecklonia Cava Extract (ECE) and pyrogallol-phloroglucinol-6,6-bieckol (PPB)
C
Comparator
High-fat diet (HFD) alone
O
Outcome
Endothelial cell dysfunction and PVAT dysfunction (measured by inflammation, ER stress, and brown adipocyte function)surrogate

ECE and its component PPB may protect against high-fat diet-induced endothelial dysfunction by modulating inflammation and brown adipocyte function in perivascular fat tissue.

Cite This Study

Son et al. (2019) studied this question.

synapsesocial.com/papers/6a7e8e86336367db4c338d0fhttps://doi.org/10.3390/nu11112795
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