Why the study?
Does bisoprolol reduce pressure overload-induced cardiac hypertrophy and fibrosis in a dose-dependent manner in a mouse model?
Population
C57BL/6J male mice, aged 6-8 weeks, subjected to aortic banding or sham surgery
Comparison
Bisoprolol at 2.5, 5, or 10 mg/kg/day for 8… vs Saline treatment (in both AB and sham groups)
Design
Preclinical, randomly assigned
Follow-up
8 weeks
Authors
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Middle-dose bisoprolol may suffice in murine pressure overload; leaves open optimal human dosing and translation to clinical HF.
Does bisoprolol reduce pressure overload-induced cardiac hypertrophy and fibrosis in a dose-dependent manner in a mouse model?
In a mouse model of pressure overload, a middle dose of bisoprolol was as effective as a high dose in preventing cardiac hypertrophy and fibrosis, suggesting that pushing to maximum target doses may not yield additional structural benefits.
Xiang et al. (2016) studied this question.
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