Why the study?
Does bisoprolol alter cardiac performance and regional blood flows in anesthetized open-chest pigs?
Population
10 anesthetized open-chest pigs
Design
Preclinical
Authors
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Highlights hemodynamic effects in porcine model; leaves open translation to human cardiac performance.
Does bisoprolol alter cardiac performance and regional blood flows in anesthetized open-chest pigs?
Bisoprolol demonstrates a dose-dependent negative chronotropic and inotropic effect without serious adverse cardiovascular effects in a porcine model, consistent with other beta-adrenoceptor agents.
Verdouw et al. (1987) studied this question.
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