Key result
Adult spontaneously hypertensive rats display ~65% higher cerebrospinal fluid ACE activity than normotensive controls.
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Angiotensin converting enzyme (ACE, Kininase II, E.C. 3.4.15.1) activity was measured in the cerebrospinal fluid of 4- and 16-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) normotensive controls. Adult SHR showed higher cerebrospinal fluid enzyme activity than normotensive age-matched WKY (19.6 +/- 1 and 32.3 +/- 5 nmol/h per ml in WKY and SHR, respectively, P less than 0.025). Conversely, there were no significant differences in enzyme activity in the cerebrospinal fluid of young animals. Our results support the hypothesis of enhanced activity of the central angiotensin system during the established phase of spontaneous hypertension in rats.
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Israel et al. (1987) studied Spontaneous hypertension (animal model). Spontaneous hypertension (SHR) vs. Age-matched Wistar-Kyoto (WKY) normotensive controls was evaluated on Cerebrospinal fluid angiotensin converting enzyme (ACE, Kininase II) activity in adult rats (nmol/h per ml) (p=<0.025). Adult spontaneously hypertensive rats had higher cerebrospinal fluid ACE activity than normotensive Wistar-Kyoto controls (32.3 vs 19.6 nmol/h/ml, P<0.025), with no difference in young rats.
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