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December 2, 2010American Journal of HypertensionOpen Access

Renal Protective Effects of Aliskiren Beyond Its Antihypertensive Property in a Mouse Model of Progressive Fibrosis

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Why the study?

Does aliskiren improve survival and reduce renal fibrosis in a nonhypertensive mouse model of progressive renal fibrosis?

Population

6-week-old COL4A3 mice already showing renal damage

Comparison

Aliskiren administered via osmotic minipumps for… vs Placebo-treated control animals

Design

Preclinical

Follow-up

Until death from renal failure

Authors

RGRainer GirgertDRDiana RubelJTJohanna Temme

Discussion

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Overview

Aliskiren may confer BP-independent renal protection in mice; leaves open translation to human CKD.

Structured PICO

Does aliskiren improve survival and reduce renal fibrosis in a nonhypertensive mouse model of progressive renal fibrosis?

P
Population
6-week-old COL4A3(-/-) mice (a nonhypertensive mouse model for progressive renal fibrosis) already showing renal damage (proteinuria ~1 g/l, starting renal fibrosis)
I
Intervention
Aliskiren administered via osmotic minipumps for 4 weeks
C
Comparator
Placebo-treated control animals
O
Outcome
Survival until end-stage renal failurehard clinical

Aliskiren prolonged survival and reduced renal fibrosis in a nonhypertensive mouse model, suggesting direct nephroprotective and antifibrotic effects independent of blood pressure lowering.

Cite This Study

Girgert et al. (2010) studied this question.

synapsesocial.com/papers/6a7e910bac06d68e91cd9d5ahttps://doi.org/10.1038/ajh.2010.231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin Inhibition Reverses Renal Disease in Transgenic Mice by Shifting the Balance Between Profibrotic and Antifibrotic Agents2013 · 19 citations
  2. 2Aliskiren Ameliorates Renal Inflammation and Fibrosis Induced by Unilateral Ureteral Obstruction in Mice2011 · 50 citations
  3. 3The use of aliskiren as an antifibrotic drug in experimental models: A systematic review2019 · 14 citations
  4. 4Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism2012 · 13 citations
  5. 5Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK- Mouse2013 · 6 citations