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December 20, 2012Lupus

Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism

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Why the study?

Does aliskiren improve proteinuria in a mouse model of lupus nephritis?

Population

6-week-old female MRL/lpr mice with lupus nephritis

Comparison

Aliskiren dissolved in phosphate-buffered… vs Phosphate-buffered saline administered via…

Design

Preclinical

Follow-up

8 weeks

Authors

TYT-H YenChang Gung UniversityYYY-H YehChang Gung UniversityPCP-H. ChuChang Gung University

Discussion

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Implication

Aliskiren may attenuate proteinuria in lupus nephritis independent of BP; hypothesis-generating and requires human validation.

Structured PICO

Does aliskiren improve proteinuria in a mouse model of lupus nephritis?

P
Population
6-week-old female MRL/lpr mice with lupus nephritis
I
Intervention
Aliskiren (20 mg/kg/day) dissolved in phosphate-buffered saline, administered via implanted Alzet mini-osmotic pumps replaced at 28-day intervals
C
Comparator
Phosphate-buffered saline administered via implanted Alzet mini-osmotic pumps
O
Outcome
Proteinuriasurrogate

Low-dose aliskiren attenuates proteinuria and renal inflammation in a mouse model of lupus nephritis through a blood pressure-independent mechanism.

Cite This Study

Yen et al. (2012) studied this question.

synapsesocial.com/papers/6a856b2a6f8d490ba41e5a28https://doi.org/10.1177/0961203312471871
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Also Consider

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  1. 1Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats2008 · 286 citations
  2. 2TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus2010 · 343 citations
  3. 3Aliskiren Ameliorates Renal Inflammation and Fibrosis Induced by Unilateral Ureteral Obstruction in Mice2011 · 51 citations
  4. 4The renin-angiotensin system in lupus: physiology, genes and practice, in animals and humans2006 · 33 citations
  5. 5Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis2009 · 96 citations