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January 1, 2013International Journal of NephrologyOpen Access

Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK- Mouse

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Key result

Aliskiren significantly decreased systolic BP and albumin-creatinine ratio, and attenuated renal fibrosis and inflammation markers in diabetic KK-A(y) mice.

Authors

MFMasako FurukawaTGTomohito GohdaSHShinji Hagiwara

Discussion

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Overview

Hypothesis-generating for aliskiren in diabetic nephropathy; human trials required before any clinical consideration.

PICO

P
Population
KK-A(y) mice with spontaneous type 2 diabetes treated with aliskiren or saline to evaluate renoprotective effects.
I
Intervention / Comparator
Aliskiren vs Untreated (saline)
O
Primary Outcome
Systolic BP, HbA1c levels, and albumin-creatinine ratio (ACR)

Cite This Study

Furukawa et al. (2013) studied Type 2 Diabetes (in KK-A(y) mice). Aliskiren vs. Untreated (saline) was evaluated on Systolic BP, HbA1c levels, and albumin-creatinine ratio (ACR). Aliskiren significantly decreased systolic BP and albumin-creatinine ratio, and attenuated renal fibrosis and inflammation markers in diabetic KK-A(y) mice.

synapsesocial.com/papers/6a89aafc755d28965dfd4f6bhttps://doi.org/10.1155/2013/519130
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Also Consider

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  1. 1Inhibition of renin activity by aliskiren ameliorates diabetic nephropathy in type 1 diabetes mouse model2012 · 12 citations
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  3. 3Renal Protective Effects of Aliskiren Beyond Its Antihypertensive Property in a Mouse Model of Progressive Fibrosis2010 · 51 citations
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  5. 5Direct renin inhibition improved insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-Ay mice2010 · 48 citations