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June 11, 2010Journal of Hypertension

Direct renin inhibition improved insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-Ay mice

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Why the study?

Does aliskiren improve insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-Ay mice?

Population

Male KK-Ay mice (type 2 diabetic model)

Comparison

Aliskiren 50 mg/kg per day administered… vs Control (implied untreated KK-Ay mice)

Design

Preclinical

Follow-up

14 days

Authors

MIMasaru IwaiHKHarumi Kan‐noYTYumiko Tomono

Discussion

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Overview

Aliskiren effects in diabetic mice remain preclinical; leaves open translation to human insulin resistance or adipose dysfunction.

Structured PICO

Does aliskiren improve insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-Ay mice?

P
Population
Male KK-Ay mice (type 2 diabetic model)
I
Intervention
Aliskiren 50 mg/kg per day administered subcutaneously via osmotic minipump for 14 days
C
Comparator
Control (implied untreated KK-Ay mice)
O
Outcome
Insulin resistance and adipose tissue dysfunction (including plasma glucose, insulin, lipids, adipose tissue mass, and gene expression)surrogate

Direct renin inhibition with aliskiren improves insulin sensitivity, reduces adipose tissue mass, and decreases oxidative stress in a mouse model of type 2 diabetes.

Cite This Study

Iwai et al. (2010) studied this question.

synapsesocial.com/papers/6a840198165e087ca0f2ed57https://doi.org/10.1097/hjh.0b013e32833bc420
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Also Consider

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  5. 5Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial2006 · 163 citations