Key result
Aliskiren significantly reduced the number of adherent leukocytes in injured mouse femoral arteries compared to PBS (18.4 vs 43.8 per 10^-2 mm^2, P<0.05).
Why the study?
Does aliskiren reduce leukocyte adhesion and vascular inflammation in mechanically-injured mouse femoral arteries and activated endothelial cells?
Population
C57BL/6 mice with perivascular cuff injury to the femoral artery, and human umbilical vein endothelial cells…
Comparison
Aliskiren administered via osmotic pump for 2… vs PBS; untreated or TNF-alpha-activated HUVECs…
Design
Preclinical
Follow-up
2 weeks of treatment, 24 hours post-injury observation
Authors
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Aliskiren may limit vascular inflammation after injury; hypothesis-generating and requires human studies before any clinical consideration.
Does aliskiren reduce leukocyte adhesion and vascular inflammation in mechanically-injured mouse femoral arteries and activated endothelial cells?
Absolute Event Rate: 18.4% vs 43.8%
p-value: p=<0.05
Aliskiren demonstrates anti-inflammatory effects in vascular injury models independent of blood pressure changes.
Ino et al. (2009) studied Vascular inflammation. Aliskiren vs. PBS was evaluated on Number of adherent leukocytes 24 hours after injury (p=<0.05). Aliskiren significantly reduced the number of adherent leukocytes in injured mouse femoral arteries compared to PBS (18.4 vs 43.8 per 10^-2 mm^2, P<0.05).
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