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July 1, 2026Tropical Journal of Natural Product ResearchOpen Access

Optimization and Validation of TLC Densitometry Method for 6-Gingerol Analysis in Orally Disintegrating Films of Zingiber officinale var. rubrum Extract

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Authors

RARegina AndayaniFNFebriyenti, Aqil Naufal,

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Overview

Randomized trial demonstrates valid measurement of 6-gingerol in orally disintegrating films using optimized TLC-densitometry.

Key Points

  • This research aims to formulate red ginger extract into orally disintegrating films and validate a TLC-densitometry method for measuring 6-gingerol.
  • Formulated orally disintegrating films (ODF) using the solvent casting method.
  • Optimized thin layer chromatography (TLC) method with silica gel and n-hexane:ethyl acetate mobile phase.
  • Method validation performed at 281 nm, assessing linearity, precision, and recovery rates.
  • The TLC-densitometry method yielded an Rf value of 0.29 ± 0.05 and showed excellent linearity (r = 0.99974).
  • 6-gingerol content was found to be 0.54% in the raw extract and 0.50% in the ODF formulation.
  • Intraday precision ranged from 1.03–1.83% and interday precision from 0.73–1.43%, with recovery rates of 98.21–100.80% for the extract.

Cite This Study

Andayani et al. (2026) studied this question.

synapsesocial.com/papers/6a7e913be7861671be8ec3d3https://doi.org/10.26538/tjnpr/v10i6.11
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