February 2, 2005Journal of Lipid ResearchOpen Access

Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I

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Structured PICO

Population

Spherical, reconstituted HDLs (rHDLs) containing apoA-I only, apoA-II only, or both apoA-I and apoA-II, and human plasma HDLs

Intervention

Incubation with endothelial lipase (EL)

Outcome

Phospholipid hydrolysis, particle size reduction, and apolipoprotein dissociationsurrogate

The phospholipase activity of endothelial lipase remodels HDLs into smaller particles without causing apolipoprotein dissociation.

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Animal data on endothelial lipase HDL remodeling should not inform therapy; leaves open functional consequences in humans.

Jahangiri et al. (2005) studied this question.

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