Why the study?
Does olmesartan plus a calcium channel blocker reduce cardiovascular risk compared to olmesartan plus a diuretic in elderly and very elderly Japanese hypertensive patients?
Does olmesartan plus a calcium channel blocker reduce cardiovascular risk compared to olmesartan plus a diuretic in elderly and very elderly Japanese hypertensive patients?
In very elderly hypertensive patients (75-84 years), combining an ARB with a CCB may be preferable to an ARB with a diuretic for reducing cardiovascular risk, particularly stroke, and has a better safety profile.
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May favor ARB plus CCB over diuretic add-on in very elderly hypertensives; extends age-stratified combination evidence from prior ARB trials.
Ogihara et al. (2014) studied this question.