Key result
Olmesartan combined with a calcium channel blocker significantly reduced visit-to-visit variability of systolic blood pressure compared to olmesartan combined with a diuretic (SD of SBP 10.02 vs 10.46, p=0.006).
Why the study?
Does olmesartan combined with a CCB reduce visit-to-visit blood pressure variability more than olmesartan combined with a diuretic in elderly hypertensive patients?
Population
4,876 hypertensive patients ages 65-84 years with a history of and/or risk factors for cardiovascular…
Comparison
Olmesartan combined with a calcium channel… vs Olmesartan combined with a diuretic for at least…
Design
RCT, randomized
Follow-up
at least 3 years
Authors
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May favor CCB over diuretic with olmesartan to reduce SBP variability; leaves open effects on outcomes.
RCT (n=4,876)
open-label, blinded-endpoint
randomized
Yes
Does olmesartan combined with a CCB reduce visit-to-visit blood pressure variability more than olmesartan combined with a diuretic in elderly hypertensive patients?
Absolute Event Rate: 10.02% vs 10.46%
p-value: p=0.006
In elderly hypertensive patients, combining olmesartan with a CCB reduces visit-to-visit systolic blood pressure variability more than combining it with a diuretic, which may mediate a preferable effect on cardiovascular events.
Rakugi et al. (2015) conducted an RCT in Hypertension (n=4,876). Olmesartan along with a calcium channel blocker vs. Olmesartan along with a diuretic was evaluated on Visit-to-visit variability of SBP (standard deviation of SBP) (p=0.006). Olmesartan combined with a calcium channel blocker significantly reduced visit-to-visit variability of systolic blood pressure compared to olmesartan combined with a diuretic (SD of SBP 10.02 vs 10.46, p=0.006).
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