Why the study?
Does cilazapril compared to dihydralazine differentially affect blood pressure response to salt intake in patients with primary hypertension?
Population
9 patients (1 female, 8 male, mean age 41 +/- 4 years) with mild to moderate primary hypertension
Comparison
Cilazapril combined with low salt and high salt… vs Dihydralazine combined with low salt and high…
Design
RCT, randomized, single blind
Authors
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Low-salt diet augments cilazapril MAP reduction unlike dihydralazine; confirms ACEIs confer salt sensitivity in primary hypertension.
Does cilazapril compared to dihydralazine differentially affect blood pressure response to salt intake in patients with primary hypertension?
ACE inhibitors like cilazapril render blood pressure salt-sensitive, whereas vasodilators like dihydralazine have similar antihypertensive effects regardless of salt intake.
Fliser et al. (1993) studied this question.
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