Why the study?
Inhibition of the renin–angiotensin system with candesartan decreases the limits of cerebral blood flow autoregulation, prompting investigation of its influence during high and low sodium intake.
Does candesartan affect the lower limit of cerebral blood flow autoregulation in rats on very high or low sodium diets?
Does candesartan affect the lower limit of cerebral blood flow autoregulation in rats on very high or low sodium diets?
Extreme variations in sodium intake (both high and low) block the expected effect of candesartan on lowering the limit of cerebral blood flow autoregulation in rats.
Answers are grounded in this paper and cite their sources.
Should not change candesartan or sodium advice in practice; leaves open human translation of this diet-ARB interaction on CBF.
Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin–angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na + ) and low (0.004% Na + ) sodium diet, respectively. Control animals were given the same diet, but no ARB. CBF was studied with the laser Doppler method. Blood pressure was lowered by controlled bleeding. Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level.
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Sigurdsson et al. (2019) studied this question.
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