Why the study?
Does removal of the carotid bodies alter eupneic arterial PCO2 and the ventilatory response to hyperoxic hypercapnia in awake dogs?
Does removal of the carotid bodies alter eupneic arterial PCO2 and the ventilatory response to hyperoxic hypercapnia in awake dogs?
Carotid bodies contribute approximately 40% of the eupneic drive to breathe in adult dogs, with no evidence of central or aortic chemoreceptor plasticity after their removal.
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Carotid bodies drive ~40% of eupneic ventilation in dogs without plasticity after removal; leaves open translation to human ventilatory control.
Rodman et al. (2001) studied this question.
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