Stress Response to Total Abdominal Hysterectomy under General Anesthesia in Type 2 Diabetic Subjects

Aims: This study was designed to investigate the hemodynamic alteration and changes of glycemic, cortisol and electrolytes status in total abdominal hysterectomy of type 2 diabetic subjects under general anesthesia. Subjects and method: Fourty subjects under general anesthesia for total abdominal hysterectomy were recruited and thrice blood samples were collected from each subject, before anesthesia (PT 0 ), 10 minutes after incision (PT 1 ) and 10 minutes after extubation (PT 2 ). Plasma glucose was measured by glucose-oxidase method, serum C-peptide and serum cortisol by chemiluminescence’s based ELISA technique (Immulite, USA). Serum electrolytes were measured by Dry Chemistry method (DT-60, USA) Results: All the subjects were hemodynamically stable during surgery. Plasma glucose increased significantly in PT2. Serum cortisol was significantly higher in PT 1 and PT 2 than PT 0 . Conclusions: Total abdominal hysterectomy under general anesthesia in well controlled type 2 diabetic subjects is accompanied by a hyperglycemic response which results from rise of insulin antagonists like cortisol.