Key result
Combined spinal epidural anaesthesia resulted in significantly lower mean cortisol concentrations 4 hours after incision compared to balanced general anaesthesia (19.96 vs 38.94 μg/dl, p=0.018).
Why the study?
Does combined spinal epidural anaesthesia reduce stress hormone and glucose concentrations compared to balanced general anaesthesia in patients undergoing major gynaecological surgeries?
Population
40 patients undergoing major gynaecological surgeries
Comparison
Combined spinal epidural anaesthesia extending… vs Balanced general anaesthesia
Design
RCT, randomly allotted
Follow-up
24 hours
Authors
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Favors combined spinal epidural anaesthesia to blunt surgical stress in gynaecological procedures; extends RCT evidence on regional techniques versus general anaesthesia.
RCT (n=40)
randomly allotted
Does combined spinal epidural anaesthesia reduce stress hormone and glucose concentrations compared to balanced general anaesthesia in patients undergoing major gynaecological surgeries?
Absolute Event Rate: 19.96% vs 38.94%
p-value: p=0.018
Combined spinal epidural anaesthesia attenuates the stress response (lower cortisol and glucose) compared to balanced general anaesthesia during major gynaecological surgeries.
Adekola et al. (2014) conducted an RCT in Major gynaecological surgeries (n=40). Combined spinal epidural anaesthesia vs. Balanced general anaesthesia was evaluated on Cortisol concentration 4 hours after incision (p=0.018). Combined spinal epidural anaesthesia resulted in significantly lower mean cortisol concentrations 4 hours after incision compared to balanced general anaesthesia (19.96 vs 38.94 μg/dl, p=0.018).
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