November 1, 1987CirculationOpen Access

Effect of graded coronary flow reduction on ionic, electrical, and mechanical indexes of ischemia in the pig.

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Population

25 open-chest pigs

Design

Preclinical

Authors

IWIsao WatanabeKyoto Prefectural University of Medicine TJTimothy A. JohnsonPurdue University West Lafayette JBJohn R. BuchananUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Hypothesis-generating in porcine ischemia; leaves open human validation before clinical adoption.

Structured PICO

Population

25 open-chest pigs

Intervention

Graded coronary flow reduction in a stepwise fashion at 5-min intervals via a carotid-to-coronary shunt

Outcome

Changes in intramyocardial extracellular potassium ([K+]e), extracellular pH (pHe), local activation, epicardial TQ-ST segment, monophasic action potential duration (MAPD), and regional contractilitysurrogate

Extracellular potassium, pH, and TQ-ST segment changes are the most sensitive indicators of myocardial ischemia during graded coronary flow reduction in a porcine model.

Cite This Study

Watanabe et al. (1987) studied this question.

synapsesocial.com/papers/6a7ea742d14c4cd8047983e5 https://doi.org/10.1161/01.cir.76.5.1127

View Full Paper

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Effect of graded coronary flow reduction on ionic, electrical, and mechanical indexes of ischemia in the pig.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of graded coronary flow reduction on ionic, electrical, and mechanical indexes of ischemia in the pig.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider