Key result
Endothelin-1 infusion limits subendocardial ischemia and yields more uniform transmural flow versus mechanical stenosis.
Why the study?
Does intracoronary ET-1 infusion alter the transmural distribution of myocardial flow and ischemia compared to mechanical stenosis in anesthetized pigs?
Population
15 anesthetized pigs
Comparison
Increasing doses of intracoronary endothelin to… vs Mechanical stenosis to reduce coronary flow 15%…
Design
Preclinical
Authors
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Should not change clinical ischemia management; leaves open ET-1 effects on transmural flow in human CAD.
Does intracoronary ET-1 infusion alter the transmural distribution of myocardial flow and ischemia compared to mechanical stenosis in anesthetized pigs?
Microvascular constriction induced by ET-1 produces a more uniform transmural distribution of myocardial flow than large-vessel mechanical stenosis.
Watanabe et al. (1995) studied Myocardial ischemia (n=15). Endothelin (ET-1) infusion vs. Mechanical stenosis was evaluated on Transmural distribution of myocardial flow and ischemia. Endothelin-1 infusion caused a more uniform transmural distribution of flow and limited subendocardial ischemia compared to mechanical stenosis at equivalent coronary flows.
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