Why the study?
Does intracoronary endothelin reduce coronary flow and myocardial shortening in anesthetized pigs?
Population
Anesthetized open-chested pigs (n=11; 6 for bolus administration, 5 for infusion)
Design
Preclinical
Authors
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Caution against clinical extrapolation from pigs; leaves open endothelin's role in human ischemic syndromes.
Does intracoronary endothelin reduce coronary flow and myocardial shortening in anesthetized pigs?
Intracoronary endothelin causes profound, persistent reductions in coronary flow and myocardial contractility, leading to lethal ischemia and ventricular fibrillation in a porcine model.
Ezra et al. (1989) studied this question.
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