Why the study?
Does atrial natriuretic peptide (ANP) induce shedding of the endothelial glycocalyx and increase vascular permeability in isolated guinea pig hearts?
Population
Isolated guinea pig hearts (n = 6/group) perfused with Krebs-Henseleit buffer in a Langendorff mode.
Comparison
Atrial natriuretic peptide at 10 M infused… vs Control group and Heparinase group.
Design
Preclinical
Follow-up
20 min
Authors
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ANP may promote edema via glycocalyx shedding in heart failure; hypothesis-generating for human translation and targeted interventions.
Does atrial natriuretic peptide (ANP) induce shedding of the endothelial glycocalyx and increase vascular permeability in isolated guinea pig hearts?
ANP increases coronary vascular permeability by inducing rapid shedding and degradation of the endothelial glycocalyx.
Bruegger et al. (2005) studied this question.
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