February 13, 2008European Journal Of Haematology

Early impairment of myocardial function in young patients with β‐thalassemia major

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Population

30 young asymptomatic patients with beta-thalassemia major and 30 healthy subjects.

Design

Case-control

Authors

DMDamiano MagrìHeart Failure / Cardiomyopathy SSSusanna SciomerHeart Failure & Transplant FFFrancesco FedeleSapienza University of Rome

Discussion

Member takes

Implication

May enable earlier myocardial monitoring in asymptomatic thalassemia; leaves open deferiprone superiority over deferoxamine pending randomized data.

Structured PICO

Population

30 young asymptomatic patients with beta-thalassemia major (16 taking deferoxamine and 14 taking deferiprone) and 30 healthy subjects.

Outcome

Differences in myocardial function assessed by echocardiography (tissue Doppler and strain imaging) and cardiac MRI (T2* technique).surrogate

Advanced ultrasound techniques like tissue Doppler and strain imaging can detect early myocardial impairment in young, asymptomatic, well-chelated patients with beta-thalassemia major.

Limitations

Needs confirmation from larger prospective studies

Cite This Study

Magrì et al. (2008) studied this question.

synapsesocial.com/papers/6a7eb603358787acda4f7c69 https://doi.org/10.1111/j.1600-0609.2008.01054.x

Topics

Echocardiography

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Implication

May enable earlier myocardial monitoring in asymptomatic thalassemia; leaves open deferiprone superiority over deferoxamine pending randomized data.

Early impairment of myocardial function in young patients with β‐thalassemia major

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Early impairment of myocardial function in young patients with β‐thalassemia major

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider