Key result
Asymptomatic patients with beta-thalassemia major had significantly lower basal lateral left ventricular strain (19.5% vs 24.2%) compared to healthy controls, indicating early regional myocardial dysfunction.
Why the study?
Does tissue Doppler, strain imaging, and FMD assessment detect early cardiovascular involvement in asymptomatic patients with beta-thalassemia major compared to controls?
Population
30 patients with beta-thalassemia major and 20 controls
Comparison
Tissue Doppler, strain, and strain rate imaging… vs Healthy controls
Design
Case-control
Authors
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Strain imaging may detect subclinical LV dysfunction in asymptomatic beta-thalassemia; leaves open prognostic utility and screening role.
Case-Control (n=50)
Single-blind
No
Does tissue Doppler, strain imaging, and FMD assessment detect early cardiovascular involvement in asymptomatic patients with beta-thalassemia major compared to controls?
Absolute Event Rate: 19.5% vs 24.196%
p-value: p=0.002
Tissue Doppler, strain, and strain rate imaging can detect early regional myocardial and endothelial dysfunction in asymptomatic beta-thalassemia patients with preserved global function.
Kapoor et al. (2017) conducted a case-control in Beta-thalassemia major (n=50). Beta-thalassemia major vs. Healthy controls was evaluated on Basal lateral left ventricular strain (p=0.002). Asymptomatic patients with beta-thalassemia major had significantly lower basal lateral left ventricular strain (19.5% vs 24.2%) compared to healthy controls, indicating early regional myocardial dysfunction.
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