Key result
Baseline mitral annular systolic velocity (Sm) <7.9 cm/s was significantly associated with the onset of adverse cardiac events in patients with beta thalassemia (P < 0.05).
Why the study?
Does tissue Doppler imaging predict adverse cardiac events in asymptomatic patients with beta thalassemia?
Cohort (n=62)
Does tissue Doppler imaging predict adverse cardiac events in asymptomatic patients with beta thalassemia?
p-value: p=< 0.05
Tissue Doppler imaging, specifically a mitral annular systolic velocity <7.9 cm/s, can identify early cardiac dysfunction and predict adverse cardiac events in asymptomatic patients with beta thalassemia.
May support risk stratification in beta thalassemia; hypothesis-generating and requires prospective validation.
BACKGROUNDS: In this study we tried to evaluate the prognostic significance of several echocardiographic parameters on the occurrence of heart failure or arrhythmias in patients with beta thalassemia. METHODS: We investigated possible differences in myocardial function between a population of 37 asymptomatic patients with beta thalassemia and 25 age-matched healthy controls, all of whom underwent an echocardiographic study, including tissue Doppler imaging (TDI), moreover plasmatic levels of N-terminal pro-BNP (NT-pro BNP) were measured in all patients. We followed the patients for 22 ± 8 months to evaluate adverse cardiac events. RESULTS: Conventional echocardiographic parameters of left ventricle were comparable in both groups. Whereas TDI peak systolic velocity (Sm) and diastolic parameter (E/Em ratio) were significantly abnormal in patients with thalassemia. Moreover eleven adverse cardiac events were observed during follow-up. Baseline systolic velocity (Sm) <7.9 cm/s was significantly associated with cardiac complications (P < 0.05). We also demonstrated that systolic velocity is inversely related to NT-proBNP plasmatic levels (P < 0.001). CONCLUSIONS: Our study suggests that mitral annular systolic velocity <7.9 cm/s is associated to the onset of adverse cardiac events.
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Marcì et al. (2010) conducted a cohort in Beta thalassemia (n=62). Baseline systolic velocity (Sm) <7.9 cm/s was evaluated on adverse cardiac events (p=< 0.05). Baseline mitral annular systolic velocity (Sm) <7.9 cm/s was significantly associated with the onset of adverse cardiac events in patients with beta thalassemia (P < 0.05).
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