Key result
In patients with beta-thalassemia major, BNP levels demonstrated a strong positive linear relationship with the E/Vp ratio (r = 0.76, P<0.001) and a U-curved association with the E/A ratio.
Population
192 consecutive patients with beta-thalassemia major and normal left ventricular systolic function.
Design
Cross-sectional
Authors
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May support noninvasive diastolic assessment in beta-thalassemia; hypothesis-generating and requires prospective validation before adoption.
Cross-Sectional (n=192)
Effect estimate: r = 0.76
p-value: p=<0.001
In young patients with beta-thalassemia major, the E/Vp ratio and tissue Doppler parameters correlate significantly with BNP levels, suggesting their utility in assessing diastolic dysfunction.
Chrysohoou et al. (2006) conducted a cross-sectional in beta-thalassemia major (n=192). BNP levels was evaluated on Relationship between BNP levels and echocardiographic diastolic parameters (r = 0.76, p=<0.001). In patients with beta-thalassemia major, BNP levels demonstrated a strong positive linear relationship with the E/Vp ratio (r = 0.76, P<0.001) and a U-curved association with the E/A ratio.
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